Beyond Vision: A View from Eye to Alzheimer’s Disease and Dementia

With the aging of global population, health care burden Alzheimer’s disease (AD) and dementia is considered to increase dramatically in coming decades. Given insufficiency effective interventions for AD dementia, clinical research on identifying potentially modifiable risk factors early diagnostic biomarkers becomes a public priority. Currently, extracerebral manifestations with large proportion ocular involvement are usually recognized precede symptoms dementia. Growing epidemiologic evidence also suggests that eye disorders, such as cataracts, age-related macular degeneration, glaucoma, diabetic retinopathy, so on, closely associated even have higher incidence The eye, an extension central nervous system, therefore has potential provide feasible approach detecting structural functional abnormalities brain. Numerous new imaging modalities developed give novel insights into detection several neurodegenerative, vascular, neuropathological, other scientific application. This review provides overview associations between disorders or summarizes recent advances examinations techniques employed more brain-and-eye interconnections being identified, becoming noninvasive easily accessible window diagnosis prevention